Diabetes patients cannot produce insulin properly which is required to convert sugar, starches, and other food source into energy. Scientists have been looking for simple and effective ways to deliver insulin into the blood stream. The most common one is taking insulin pill orally. However research shows that insulin is easily broken down by the digestive system. This problem is solved by using chewing gum insulin. Compositions containing a therapeutic peptide covalently linked to Vitamin B12 at the 5'-hydroxyl group of the ribose moiety of a-ligand are described. The length of the linkage is optimized so that the biological activity of both the Vitamin B12 and the therapeutic peptide is maintained. Therapeutic peptide includes insulin, PYY, NPY and GLP-1. Attachment to Vitamin B12 provides uptake of the therapeutic peptide from the digestive tract and longer residence time.
Loading....